解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To evaluate the effects of the transcription factor GATA-1 on determining cell fate between dendritic cell (DC) and mast cell (MC) lineages, GATA-1 was exogenously expressed in bone marrow-derived (BM) DCs. Exogenous expression of GATA-1 by a retrovirus in BMDCs inhibited expression of CD11c, CD80, CD86, and major his...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0444-1
更新日期:2010-07-01 00:00:00
abstract::Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0441-4
更新日期:2010-06-01 00:00:00
abstract::Ranatuerins are antimicrobial peptides of the innate immune system found in ranid frogs. We previously presented evidence that a positive selective sweep had fixed a single allele at the Ranatuerin2 locus in the northern leopard frog (Rana pipiens). In this paper, we further investigate the evolutionary history of ran...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0430-7
更新日期:2010-05-01 00:00:00
abstract::Polymorphic insertion frequencies of the retrotransposons known as the "SVA" elements were investigated at four loci in the MHC class I genomic region to determine their allele and haplotype frequencies and associations with the HLA-A, -B or -C genes for 100 Japanese, 100 African Americans, 174 Australian Caucasians a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0427-2
更新日期:2010-04-01 00:00:00
abstract::The MHC class I gene family of rhesus macaques is characterised by considerable gene duplications. While a HLA-C-orthologous gene is absent, the Mamu-A and in particular the Mamu-B genes have expanded, giving rise to plastic haplotypes with differential gene content. Although some of the rhesus macaque MHC class I gen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0424-5
更新日期:2010-03-01 00:00:00
abstract::To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from the Philippines, Indonesia, and Vietnam). In total, we characterized 22 cDNA DRA alleles, 13 of which had not...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0421-8
更新日期:2010-03-01 00:00:00
abstract::Loss of major histocompatibility complex class II (MHCII) antigen expression on diffuse large B cell lymphoma (DLBCL) corresponds closely with significant decreases in patient survival. However, the mechanisms accounting for MHCII loss in DLBCL have not been thoroughly characterized to date. In this report, we demonst...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0418-3
更新日期:2010-02-01 00:00:00
abstract::Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0387-6
更新日期:2009-08-01 00:00:00
abstract::The restricted diversity of the major histocompatibility complex (MHC) of Mauritian cynomolgus macaques provides powerful opportunities for insight into host-viral interactions and cellular immune responses that restrict lentiviral infections. However, little is known about the effects of Mhc haplotypes on control of ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0369-8
更新日期:2009-05-01 00:00:00
abstract::The polymorphic major histocompatibility complex (MHC) has gained a specific relevance in pathogen resistance and mate choice. Particularly the antigen-binding site (ABS), encoded by exon 2 of the DRB class II gene, exhibits numerous alleles and extensive sequence variations between alleles. A lack of MHC variability ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0362-2
更新日期:2009-04-01 00:00:00
abstract::Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0352-9
更新日期:2009-03-01 00:00:00
abstract::Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic region (called HLA) is extremely polymorphic comprising several thousand alleles, each encoding a distinct MHC molecule. The pot...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0341-z
更新日期:2009-01-01 00:00:00
abstract::The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0334-y
更新日期:2008-12-01 00:00:00
abstract::We describe a bioinformatic analysis of germline and rearranged immunoglobulin kappa chain (IGK) gene sequences, performed in order to assess the completeness and reliability of the reported IGK repertoire. In contrast to the reported heavy-chain gene repertoire, which includes many dubious sequences, only five IGK va...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0325-z
更新日期:2008-11-01 00:00:00
abstract::Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0275-5
更新日期:2008-04-01 00:00:00
abstract::Several lines of evidence have confirmed the importance of Nod2 mutations for disease susceptibility in Crohn's disease. For tracing Nod2 evolution, exons 4a, 4e, 8, and 12 mutations were screened in a collection of 1,064 DNA samples from 52 worldwide populations. The overall allele frequency was 7.5% for single nucle...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0274-6
更新日期:2008-02-01 00:00:00
abstract::The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate im...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-007-0248-0
更新日期:2007-10-01 00:00:00
abstract::The KIR gene cluster exhibits a high degree of polymorphism in terms of gene content as well as allelic polymorphism, and data suggest that it is evolving rapidly. The KIR3DL1 locus is one of the most polymorphic loci within this cluster and is unique in that it encodes an activating receptor KIR3DS1, as well as multi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0240-8
更新日期:2007-10-01 00:00:00
abstract::To determine the nucleotide polymorphism of activating killer-cell immunoglobulin-like receptors (aKIR) 3DS1 and 2DS3, we developed a novel direct-sequencing method and analyzed DNA samples of 175 KIR3DS1(+) individuals and 72 KIR2DS3(+) individuals from the white population. The putative ligand-binding extracellular ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0239-1
更新日期:2007-10-01 00:00:00
abstract::Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0235-5
更新日期:2007-08-01 00:00:00
abstract::The generation and maintenance of allelic polymorphism in genes of the major histocompatibility complex (MHC) is a central issue in evolutionary genetics. Recently, the focus has changed from ex situ to in situ populations to understand the mechanisms that determine adaptive MHC polymorphism under natural selection. B...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0205-y
更新日期:2007-05-01 00:00:00
abstract::There have been several attempts over the years to identify positions in the peptide-binding region (PBR) of human leukocyte antigens (HLA) that influence the specificity of bound amino acids (AAs) at each position in the peptide. Originally, six pockets (A-F) were defined by calculating the surface area of the PBR on...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0197-7
更新日期:2007-04-01 00:00:00
abstract::Human leucocyte antigen (HLA)-DRB1*15 is associated with predisposition to multiple sclerosis (MS), although conjecture surrounds the possible involvement of an alternate risk locus in the class I region of the HLA complex. We have shown previously that an alternate MS risk allele(s) may be encompassed by the telomeri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0183-5
更新日期:2007-03-01 00:00:00
abstract::Earlier studies suggest that end-stage renal disease (ESRD) is associated with inflammatory state and have become a major cause of morbidity and mortality worldwide. This study speculated the role of interleukins (IL)-2, -4, and -6 cytokines gene polymorphism with risk of susceptibility to ESRD. Polymorphism in IL-2 (...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0182-6
更新日期:2007-02-01 00:00:00
abstract::Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0186-2
更新日期:2007-02-01 00:00:00
abstract::We have previously reported that autoimmune pancreatitis (AIP) is a bioclinical entity characterized by high serum immunoglobulin G4 concentrations and association with the HLA-DRB1*0405-DQB1*0401 haplotype. However, the precise identity of gene(s) within this haplotype directly responsible for AIP pathogenesis is yet...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0178-2
更新日期:2007-01-01 00:00:00
abstract::The recent identification of a large and diverse family of leukocyte immune-type receptors (IpLITRs) in channel catfish (Ictalurus punctatus) indicates that immunoglobulin superfamily (IgSF) members related to both mammalian Fc receptors (FcRs) and leukocyte receptor complex (LRC)-encoded proteins exist in fish. In th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0169-3
更新日期:2007-01-01 00:00:00
abstract::Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; howeve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0164-8
更新日期:2006-12-01 00:00:00
abstract::Genes encoding the immunoglobulin heavy-chain variable region (Ig VH) in rainbow trout (Oncorhynchus mykiss) have been grouped into 11 families. While obtaining a baseline assessment of the various gene families utilized by trout in the production of secreted antibody, we discovered two new families. These proposed Ig...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0149-7
更新日期:2006-11-01 00:00:00
abstract::T cell receptor genes are assembled in developing T lymphocytes from discrete V, D, and J genes by a site-specific somatic rearrangement mechanism. A flanking recombination signal, composed of a conserved heptamer and a semiconserved nonamer separated by 12 or 23 variable nucleotides, targets the activity of the rearr...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0150-1
更新日期:2006-11-01 00:00:00
abstract::Antigen-specific CD4+ T cells play a critical role in protective immunity to many infectious pathogens. Although the antigen-specific CD4+ T cells can be measured by functional assays such as proliferation or cytokine enzyme-linked immunospot, such assays are limited to a specific function and cannot quantify anergic ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0140-3
更新日期:2006-09-01 00:00:00
abstract::Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0122-5
更新日期:2006-08-01 00:00:00
abstract::The N-terminal domain of the chemokine CCL5/regulated upon activation normal T cell expressed and secreted (RANTES) has been shown to be critical for its biological activity on leukocytes. Several N-terminus-modified CCL5/RANTES derivatives, such as N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (A...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0133-2
更新日期:2006-07-01 00:00:00
abstract::In the African clawed frog (Xenopus laevis), two deeply divergent allelic lineages of multiple genes of the class I MHC region have been discovered. For the MHC class I UAA locus, functional differences and the molecular basis for lineages maintenance are unknown. Alleles of linked class I region genes also exhibit st...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0114-5
更新日期:2006-06-01 00:00:00
abstract::The Hawaiian monk seal population has experienced precipitous declines in the last 50 years. In this study, we provide evidence that individuals from remaining endangered population exhibit alarming uniformity in class I major histocompatibility (MHC) genes. The peripheral blood leukocyte-derived mRNA of six captive a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0069-y
更新日期:2006-04-01 00:00:00
abstract::We have performed an extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression. The coding regions and promoters of these genes were sequenced in the genetics of resistance to immunodeficiency virus cohort, composed...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0072-3
更新日期:2006-04-01 00:00:00
abstract::Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0077-y
更新日期:2006-02-01 00:00:00
abstract::The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0054-5
更新日期:2005-12-01 00:00:00
abstract::The variability of immune responses modulated by human leukocyte antigen (HLA) genes and secreted cytokines is a significant factor in the development of a protective effect of measles vaccine. We studied the association between type 1 helper T cells (Th1)- and Th2-like cytokine immune responses and HLA class I allele...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0061-6
更新日期:2005-12-01 00:00:00
abstract::Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0024-y
更新日期:2005-10-01 00:00:00